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Department of Pharmacy

  

Department Faculties

  

Dr. Pratap Chandra Acharya

Name: Dr. Pratap Chandra Acharya
Date of Birth : 31/12/1982
Phone number's : +91-381-2379406 +91-7738441967
E-mail's : pratapacharya[at]tripurauniv.ac.in
Academic Qualifications : M.Pharm., Ph.D.
Present Designation/position : Assistant Professor
Topics Taught : Medicinal Chemistry; Organic Chemistry; Biochemistry and Pharmaceutical analysis.
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1.

PhD (2013): Panjab University, Chandigarh

Thesis Title: Synthesis and pharmacological evaluation of some newer heterosteroids as antineoplastic agents.”

2.

M.Pharm (2008): IIT (BHU), Varanasi

Thesis Title: Design, synthesis and anticonvulsant evaluation of some new 1,3,4-thiadiazole derivatives

3.

B.Pharm (2006): Berhampur University, Berhampur/ BPUT, Odisha.

4.

P.G.Diploma in Spectroscopy (Dual Degree; 2008): BHU, Varanasi

 

PUBLICATIONS

Papers in Journal

  1. Marwein, S.; Mishra, B.; De, U. C.; Acharya, P. C.* Recent Progress of Adenosine Receptor Modulators in the Development of Anticancer Chemotherapeutic Agents. Current Pharmaceutical Design 2019, https://doi.org/10.2174/ 1381612825666190716141851
  2. Palmer, R. A.; Lisgarten, D. R.; Cockcroft, J. K.; Lisgarten, J. N.; Talbert, R.; Dines, T.; Bansal, R.; Acharya, P. C.; Suryan, A. Crystal and Molecular Structure and DFT Calculations of the Steroidal Oxime 6E-Hydroximino-androst-4-ene-3,17-dione (C19H25NO3) a Molecule with Antiproliferative Activity. Journal of Chemical Crystallography 2019, 49, 29-36.
  3. Fernandes, C.; Acharya, P. C*.; Bhatt, S. Preparation of lauroyl grafted alginate-psyllium husk gel composite film with enhanced physicochemical, mechanical and antimicrobial properties. Scientific Reports 2018, 8, 17213.
  4. Acharya, P. C.; Bansal, R.; Kharkar, P. S. Hybrids of steroid and nitrogen mustard as antiproliferative agents: Synthesis, in vitro evaluation and in silico inverse screening, Drug Research 2018, 68, 100-103.
  5. Acharya, P. C.; Bansal, R. Synthesis of androstene oxime-nitrogen mustard bioconjugates as potent antineoplastic agents. Steroids 2017, 123, 73-83.
  6. Ghosh, R.; Jajo, H.; Acharya, P. C.* An Overview of Neptunia prostrata: A Source of Herbal Medicine of Ethnopharmacological Importance. Glob. J. Pharmaceu. Sci.  2017, 2.
  7. Acharya P. C.*; Vasi, R.; Suares, D. FTIR assay method for UV inactive drug carisoprodol and identification of degradants by RP-HPLC and ESI-MS. J. Chromatogr B. 2016, 1030, 16-21.
  8. Kumar P.; Watts A.; Acharya P.; Bansal R.; Ghai A.; Kaur A.; Singh B. Radiosynthesis of [18F]-fluorobenzoate-doxorubicin using Acylation approach. Current Radiopharmaceuticals, 2016, 9, 215-221.
  9. Bansal R.; Acharya P. C. Man-made cytotoxic steroids: Exemplary agents for cancer therapy. Chemical Reviews 2014, 114, 6986-7005.
  10. Acharya P. C.; Bansal R. Synthesis and antiproliferative activity of hydroximino androstene derivatives. Arch. Pharm. Chem. Life Sci. 2014, 347, 193-199.
  11. Acharya P. C.* Targeting cancer through angiogenesis inhibition: Prospective of azole based small molecules. Research & Reviews: A Journal of Drug Design & Discovery 2014, 1, 13-18.
  12. Bansal, R.; Guleria,A.; Acharya, P. C. FT-IR method development and validation for quantitative estimation of zidovudine in bulk and tablet dosage form. Arzneimittelforschung/Drug Research. 2013, 63, 165-170.  
  13. Bansal R.; Acharya P. C. Synthesis and antileukemic activity of 16E-[4-(2-carboxy)ethoxybenzylidene]-androstene amides. Steroids 2012, 77, 552-557.
  14. Awen, B. Z.; Hawisa, N. T.; Katakam, P.; Rao, C. B.; Adiki, S. K.; Acharya, P. C. Antidiarrhoeal activity of Lippia javanica leaves on castor oil induced diarrhoea in albino rats. Pharmanest 2011, 2, 5-8.

Book Chapters

  1. Acharya, P. C.; Shetty, S.; Fernandes, C.; Suares, D.; Maheshwari R.; Tekade, R. K. Preformulation in Drug Research and Pharmaceutical Product Development. In Dosage form design considerations, Vol 1, Elsevier Academic Publisher, 2018, pp 1-55.
  2. Acharya, P. C.; Fernandes, C.; Mallik, S.; Mishra B.; Tekade, R. K. Physiologic Factos Related to Drug Absorption. In Dosage form design considerations, Vol 1, Elsevier Academic Publisher, 2018, pp 117-147.
  3. Acharya, P. C.; Marwein, S.; Mishra B.; Ghosh, R.; Vora A.; Tekade, R. K. Role of Salt Selection in Drug Discovery and Development. In Dosage form design considerations, Vol 1, Elsevier Academic Publisher, 2018, pp 435-472.
  4. Acharya, P. C.; Fernandes, C.; Suares, D.; Shetty, S.; Tekade, R. K.  Solubility and Solubilization Approaches in Pharmaceutical Product Development. In Dosage form design considerations, Vol 1, Elsevier Academic Publisher, 2018, pp 513-547.
  5. Acharya, P. C.; Suares, D.; Shetty, S.; Fernandes, C.; Tekade, R. K. Rheology and its Implications on Performance of Liquid Dosage Forms. In Dosage form design considerations, Vol 1, Elsevier Academic Publisher, 2018, pp 549-597.

 

CONFERENCE PROCEEDINGS

  1. Kumar, P.; Singh, B.;  Chopra, S.; Acharya, P.; Sarika.; Bansal, R.; Mittal, B. Synthesis, characterization and radiolabeling of DTPA-Doxorubicin complexed with 68Ga as potential PET tumor imaging agent-A preclinical evaluation. World J. Nucl. Med. 2013, 12 (Suplement 1), 44.
  2. Kumar, P.; Singh, B.;  Acharya, P.; Bansal, R.; Watts, A.; Ghai, A.; Mittal, B.; Dhawan, D. Synthesis of 18F-fluorobenzoate doxorubicin as a potential PET radiotracer for tumor imaging. J. Nucl. Med. 2012, 53 (Supplement 1), 1653.
  3. Acharya, P. C.; Raja, A. S.; Putta, A. Anticonvulsant investigation of some substituted semicarbazones by maximal electroshock seizure test model. Indian J. Pharmacol. 2008, 40 (supplement 2), s121.

Selected Abstracts

  1. Marwein, S.; Acharya, P. C.* Synthesis and antiproliferative evaluation of some newer spiroindanedione derivatives, IUPAC Paris 2019, July 7 to July 12, 2019 at Le Palais des Congrès of Paris, France.
  2. Acharya, P. C.* Ghosh, R.; Paulo, A.; Vitor, J.; Mendes, E. Stereoselective synthesis of spirooxindole derivatives and evaluation of their anticancer efficacy through in vitro G-quadruplex interaction and cytotoxicity assay, IUPAC Paris 2019, July 7 to July 12, 2019 at Le Palais des Congrès of Paris, France.
  3. Acharya, P. C.*, Fernandes, C.; Mehta, S.; Synthesis of alpha-tocopherol and medium chain fatty acid conjugates with enhanced biological profile, International Symposium on Bioorganic Chemistry (ISBOC-11) & Konstanz Symposium Chemical Biology, University of Konstanz, Germany, 27th to 29th Septemeber 2017.
  4. Acharya, P. C.*, Bhowmik, B.; Bhattacharjee, S.; Das, P., Spiroisoxazoline fused steroid derivatives as target specific antineoplastic agents, International Conference on Updates in Cancer Prevention and Research (ICUCPR-2017), Lucknow, 14th  -16th  February 2017.
  5. Marwein, S.; Acharya, P. C.*, Spiroisoxazoline scaffold in the antineoplatic drug discovery, International Conference on Updates in Cancer Prevention and Research (ICUCPR-2017), Lucknow, 14th  -16th  February 2017.
  6. Ghosh, R.; Acharya, P.  C.* Spirocyclic oxindole scaffold as an emerging pharmacophore in the anticancer drug discovery, International Conference on "Updates in Cancer Prevention and Research (ICUCPR-2017), Lucknow, 14th  -16th  February 2017.
  7. Acharya, P. C.; Bansal, R.; Kharkar, P. S. “Hybrids of steroid and nitrogen mustard as antileukemic agents: Design, synthesis, biological evaluation and in silico inverse screening”. International Conference on Pure and Applied Chemistry 2014, Mauritius, 23rd -27th  June 2014.
  8. Vasi, R.; Acharya, P.  C.* “FTIR Method development and validation of carisoprodol in bulk and tablet dosage form”. National Conference on Drug Discovery and Drug Targeting in Metabolic Diseases. Dr. Bhanuben Nanavati College of Pharmacy, Mumbai, 22nd -23rd December, 2014
  9. Acharya, P.  C.; Bansal, R. “Discovery of cancer specific molecules from steroids: Synthesis of 16E-arylidene androstenes as potent antileukemic agents”. Manshodhan-IV, Mithibai College, Mumbai, 14th December 2013.
  10. Chanan, N.; Acharya, P.  C.; Bansal, R. “Synthesis and cytotoxic activity of 6E-hydroximino androstenes and their oxime ethers”. 64th Indian Pharmaceutical Congress, Chennai, 7-9th December 2012.
  11. Khushpal, Bansal, R.; Guleria, A.; Acharya, P. C. “FT-IR method development and validation for quantitative estimation of zidovudine in bulk and tablet dosage form”. 64th Indian Pharmaceutical Congress, Chennai, 7-9th December 2012.
  12. Acharya, P. C.; Bansal, R. Synthesis of 16E-[4-(2-carboxy)ethoxy benzylidene]-androstene amides as potent antileukemic agents. 63rd Indian Pharmaceutical Congress, Bengaluru, 16th-19th December, 2011.
  13. Acharya, P. C.; Bansal, R.; Guleria, S.; Harvey, A. L. Synthesis of bisquaternary ammonium salts of 16E-[4-(2-alkylaminoethoxy)-3-methoxybenzylidene]androstene derivatives as skeletal muscle relaxants. 62nd Indian Pharmaceutical Congress, Manipal University, Manipal. 17-19 December, 2010.
  14. Vijay, S. R.; Acharya, P. C.; Singh, G. “Study of elimination of Aspirin from a fixed dose formulation in healthy human volunteers”. National Pharmacy Conference. Apex Institute of Pharmaceutical sciences, Jaipur, 24-27 July 2009.
  15. Acharya, P. C.; Bansal, R. “Steroidal alkylating agents in hormone responsive cancer chemotherapy”. XXVth Annual conference of Environmental Mutagen Society of India and International Symposium on Mutagens and Genetic Diversity for Health and Agriculture, Panjab University, Chandigarh, 12-14th March 2010.
  16. Acharya, P. C.; Raja, A. S.; Putta, A.; Nath, G. “Synthesis and preliminary antibacterial investigation of 4-flouro and 2, 4-dichloro substituted aryl semicarbazones”. 59th Indian Pharmaceutical Congress, Banaras Hindu University, Varanasi. Scientific Abstract 59th IPC, (2007), 146-147.

 

1.

“European Molecular Biology Organization Short Term Fellowship-2018 (EMBO STF-2018)” award

2.

“DST Young Scientist International Travel Grant Award” by Department of Science and Technology, Government of India, 2017

3.

“Science Academies' Summer Research Fellowship-2017” Jointly awarded by Indian Academy of Sciences, Bengaluru (IASc), Indian, National Science Academy, New Delhi (INSA), and The National Academy of Sciences, Allahabad (NASI), India

4.

“University Grant Commission Research Fellowship for Meritorious Student in Science (UGC-RFSMS)-2009” to pursue Ph.D at Panjab University, Chandigarh

5.

“G.A.T.E Fellowship (Ministry of Human Resource Development, Govt. of India) Year 2006”, conducted by IIT-Kharagpur.

6.

“Best Paper in Medicinal Chemistry award” and “Best Oral Presentation Award” at 63rd Indian Pharmaceutical Congress, Bengaluru, India, 16th-18th December 2011.

7.

“Research Project Presentation” award at Manshodhan-IV, Mithibai College, Mumbai, India, 14th December 2013 for Anti-cancer drug discovery.

 

SPONSORED RESEARCH PROJECTS

Title of project

Funding agency

Sanctioned budget

Project duration

From

To
  1. Targeting colon cancer through lipidized antioxidants: Synthesis, purification, characterization and biological evaluations of fatty acid conjugated phenolic antioxidants

UGC,

New Delhi

10 Lakh

22/02/2017

22/02/2019
  1. Stereoselective synthesis of heterosteroidal spirocyclic oxindoles as antineoplatic agents

CSIR,

New Delhi

20.12 Lakh

01/11/2017

30/10/2020
  1. Investigation of hydrophobically modified polysaccharides for nanodelivery of anticancer drugs in the treatment of multidrug resistance colon cancer

DBT, New Delhi

65.964 Lakh

28/01/2019

27/01/2021
  1. Phytochemical and pharmacological evaluations of bioactivity guided fractions of medicinal plants of Tripura

DBT, New Delhi

73.918

28/09/2018

27/09/2021

 

ORIENTATION PROGRAM/SEMINARS/ GUEST LECTURES

  1. Participated in a two day conference “3rd Meeting of the College of Chemistry (3ECQUL) at the University of Lisbon, Portugal” from 27th -28th June 2018.
  2. Participated in the Faculty Induction Training Institutes under Pandit Madan Mohan Malaviya National Mission on Teachers and Teaching (PMMMNMTT) Scheme of MHRD, Govt of India, conducted by FDC, Tripura University from 1st November, 2017 to 30th  November, 2017 and secured A+ grade.
  3. Participated in the Faculty Induction Training Institutes under Pandit Madan Mohan Malaviya National Mission on Teachers and Teaching (PMMMNMTT) Scheme of MHRD, Govt of India, conducted by FDC, Tripura University from 13th November, 2016 to 19th  November, 2016.
  4. Organized and participated in one day “National Seminar on techno-managerial skills for Pharmaceutical Industry". (4th January 2016, SVKM’S NMIMS, Mumbai)
  5. Organized and participated in two day “National Conference on Nanotechnology in Drug Delivery Research: Innovations, Challenges & Opportunities” (16-17th October, 2015, SVKM’S NMIMS, Mumbai).
  6. Delivered a guest lecture on the topic “Targeting Cancer through Steroid Motifs: A Prudent Approach in Anticancer Drug Discovery” at University of Pune Sponsored National Seminar on Current Strategies in Targeting Tyrosine  Kinase for Anticancer Research, 22nd  Jan 2015 held at Sinhgad College of Pharmacy, Pune.
  7. Participated in one day seminar on “Advances in spectroscopy and chromatographic techniques” on 8th January 2014 held at SPPSPTM, SVKM’S NMIMS, Mumbai.
  8. Attended National Conference on “Innovation in pharmaceutical technology and healthcare management”, 10th -11th January, 2014 held at SPTM, SVKM’S NMIMS, Shirpur Campus.

 

 

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